Welcome to the Population Approach Group in Europe

Tuesday June 2
14:00-18:30	Registration

19:30	Welcome reception

Wednesday June 3
08:00-09:00	Registration

09:00-09:15	Welcome and Introduction

09:15-10:45	Targeting Ebola		Chair: Steven Kern
09:15-09:30	Steven Kern	Conducting clinical trials in challenging environments
09:30-09:55	France Mentré	Estimating an effective dose for a repurposed drug to treat Ebola: the case of favipiravir
09:55-10:20	Matthias Machacek	Estimating an effective dose for a new drug to treat Ebola with incomplete information: the case of Zmapp
10:20-10:45	Scott Berry	An Adaptive Platform Trial for Ebola: Application to Future Epidemics

10:45-12:15	Coffee break, Poster and Software session I
	Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter

12:15-12:55	Diabetes		Chair: IñakiTrocóniz
12:15-12:35	Roberto Bizzotto	A model of glucose clearance to improve the description of glucose homeostasis
12:35-12:55	Rada Savic	A longitudinal HbA1c model elucidates genes linked to disease progression on metformin therapy

12:55-14:25	Lunch

14:25-15:15	On the 20th anniversary of 'Nonlinear models for repeated measurement data'		Chair: France Mentré
14:25-14:50	David Giltinan	Why write a book in 1995 on nonlinear mixed effects modeling?
14:50-15:15	Marie Davidian	Subsequent developments in nonlinear mixed effects modeling (link to the video of the presentation)

15:15-16:40	Tea break, Poster and Software session II
	Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter

16:40-17:40	Other diseases		Chair: Ana Ruiz
16:40-17:00	José David Gómez-Mantilla	Towards patient stratification and treatment in the autoimmune disease lupus erythematosus using a systems pharmacology approach
17:00-17:20	Gopichand Gottipati	Modeling of a composite score in Parkinson’s disease using item response theory
17:20-17:40	Emilie Hénin	Determination of effective blood concentrations of cyclosporine in pediatric severe aplastic anemia based on a time-to-response model

Thursday June 4
09:00-10:20	Lewis Sheiner Student Session		Chair: Rada Savic, Steven Kern and Michael Looby
09:00-09:25	Huixin Yu	Development of a tumour growth inhibition model to elucidate the effect of ritonavir on intratumoural metabolism and anti-tumour effect of docetaxel in a mouse model for hereditary breast cancer
09:25-09:50	Shan Pan	Automated proper lumping for simplification of systems models
09:50-10:15	Adrien Tessier	Modelling pharmacogenetic data in population studies during drug development
10.15-10.20	Presentation of Lewis Sheiner student session awards

10:20-11:45	Coffee break, Poster and Software session III
	Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter

11:45-12:50	Applied Bayesian Inference for Pharmacometrics		Chair: Paolo Magni
11:45-12:05	Michael Betancourt	Part I: Building Robust PK/PD Population Models with Bayesian Inference
12:05-12:30	Sebastian Weber	Part II: Building Robust PK/PD Population Models with Bayesian Inference
12:30-12:50	Thierry Wendling	Application of a Bayesian population approach to physiologically-based modelling and simulation of mavoglurant pharmacokinetics

12:50-14:10	Lunch

14:10-15:10	PKPD and drug resistance in infectious diseases		Chair: Oscar Della Pasqua and Jonathan Mochel
14:10-14:30	Rong Deng	Towards Model-Based Drug Development of New Therapeutics for Hepatitis C Virus
14:30-14:50	Joe Standing	Treating resistant Gram-negatives: bedside to bench and back
14:50-15:10	Anders Kristoffersson	A PKPD model characterizing resistance for predictions of bacterial kill in vivo

15:10-15:15	Announcement of WCoP 2016		Nick Holford

15:15-16:30	Tea break, Poster and Software session IV
	Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter

16:30-17:30	Stuart Beal Methodology Session		Chair: Pascal Girard
16:30-16:50	Andrew Hooker	Preconditioning of nonlinear mixed effect models for stabilization of the covariance matrix computation
16:50-17:10	Eric Strömberg	Simulated model based adaptive optimal design of adult to children bridging study using FDA stopping criteria
17:10-17:30	Sebastian Ueckert	Alternative to resampling methods in maximum likelihood estimation for NLMEMs by borrowing from Bayesian methodology

Friday June 5
09:15-10:15	Infectious diseases		Chair: Marylore Chenel
09:15-09:35	Joel Tarning	Semi-mechanistic time-to-event modelling in malaria
09:35-09:55	Natalie Filmann	Modeling the PK/PD of hepatitis B immunoglobulin after hepatitis B induced liver transplantation by an extended target mediated drug disposition model
09:55-10:15	Dimitra Bon	Multiscale modelling for hepatitis C treatment

10.15-10.25	Preview of PAGE 2016

10:25-10:55	Coffee break and Software session

10:55-12:15	Modelling in oncology		Chair: Dinesh De Alwis
10:55-11:15	Nadia Terranova	Analysis of individual target lesions for tumor size models of drug resistance: a new methodology encompassing signal processing and machine learning
11:15-11:35	Nelleke Snelder	PKPD modelling of the relationship between testosterone and PSA in patients with prostate cancer during treatment with leuprorelin – What is the optimal testosterone level?
11:35-11:55	Anna Georgieva Kondic	Model-based analysis of the relationship between pembrolizumab exposure and efficacy in patients with melanoma and NSCLC: across indication comparison
11:55-12:15	Pauline Mazzocco	Modeling the emergence of resistance in low-grade glioma patients treated with temozolomide, and simulations using a stochastic approach

12.15-12.25	Closing remarks

12:25-12:45	Audience Input for the PAGE 2016 Program