2012 - Venice - Italy

Tuesday June 5
14:00-18:00	Registration
18:00-20:00	Opening ceremony and welcome reception
Wednesday June 6
08:00-08:40	Registration
08:40-08:55	Welcome and introduction
08:55-09:00	In memoriam Hans Schaefer
09:00-10:15	Panel discussion: modelling and simulation and the regulatory process		chair: Joachim Grevel
	Panel members: Terry Shepard, Gerard Pons, Peter Milligan, Mick Looby, Leon Aarons, Nick Holford
10:15-11:45	Coffee break, poster and software session I
	Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:45-12:25	Model-based evaluations		chair: Charlotte Kloft
11:45-12:05	Bruno Bieth	Model-based analyses for pivotal decisions, with an application to equivalence testing for biosimilars
12:05-12:25	Sylvain Goutelle	A unified in vivo modeling approach for quantitative prediction of the impact of gene polymorphism and drug interactions on drug exposure
12:25-12:30	Launch of the new journal 'CPT: Pharmacometrics & Systems Pharmacology'		speaker: France Mentré
12:30-12:35	The International Society of Pharmacometrics		speaker: Marc Pfister
12:35-12:40	The World Conference on Pharmacometrics (WCoP)		speaker: Kyungsoo Park
12:40-14:05	Lunch
14:05-14:55	The placebo response		chair: Oscar Della Pasqua
14:05-14:55	Fabrizio Benedetti	Tutorial: The neurobiology of placebos
14:55-15:15	Jakob Ribbing	Literature Model for FEV1 in COPD Trials – Separating the Dynamic Components of Placebo Effect, Disease Progression and Interacting Drug Effects
15:15-16:45	Tea break, poster and software session II
	Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:45-17:45	Glucose and hemoglobin modelling		chair: Nick Holford
16:45-17:05	Thomas Eissing	A physiologically-based PK/PD model to capture population variability for diabetes research and automatic blood glucose control
17:05-17:25	Maria Kjellsson	Predicting late-phase outcome from early-phase findings using a Model-Based Approach – Application to Type 2 Diabetes Mellitus
17:25-17:45	Franziska Schädeli Stark	Semi-physiologic population PKPD model characterizing the effect of bitopertin (RG1678) glycine reuptake inhibitor on hemoglobin turnover in humans
Thursday June 7
08:45-10:05	Oncology		chair: René Bruno
08:45-09:05	James Yates	Applying mechanistic pharmacokinetic-pharmacodynamic models (PKPD) to describe the growth and inhibition of xenograft tumours in rats and mice by targeted anti-cancer agents
09:05-09:25	Ben-Fillippo Krippendorff	Relationship between the dose of therapeutic antibodies and the inhibition of cytoplasmic and nuclear growth factor signalling
09:25-09:45	Mélanie Wilbaux	Population K-PD joint modelling of tumor size and CA 125 kinetics after chemotherapy in relapsed ovarian cancer (ROC) patients
09:45-10:05	Ekaterina Gibiansky	PK/PD modeling and optimization of eltrombopag dose and regimen for treatment of chemotherapy-induced thrombocytopenia (CIT) in cancer patients
10:05-11:35	Coffee break, poster and software session III
	Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:35-12:30	Lewis Sheiner student session		chairs: Dinesh Dealwis, Katya Gibiansky, Pascal Girard
11:35-12:00	Thomas Dorlo	Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive cover after use of miltefosine for the treatment of visceral leishmaniasis
12:00-12:25	Sebastian Ueckert	Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease
12:25-12:30	Presentation of awards
12:30-14:00	Lunch
14:00-15:00	Markov modelling		chair: Lutz Harnisch
14:00-14:40	Mats Karlsson	Tutorial: Introduction to Markov modelling
14:40-15:00	Oliver Ackaert	A hidden Markov model to assess drug-induced sleep fragmentation
15:00-16:30	Tea break, poster and software session IV
	Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:30-17:30	Stuart Beal methodology session		chair: France Mentré
16:30-16:50	Chee Ng	Novel Hybrid Artificial Neural Network-Nonlinear Mixed Effect Model Modeling Approach for Population Data Analysis in Model-based Drug Development
16:50-17:10	William Denney	N-dimensional Likelihood Profiling: An Efficient Alternative to Bootstrap
17:10-17:30	Gilbert Koch	Modeling of delayed phenomena in PKPD by delay differential equations of lifespan type
	Social evening
Friday June 8
09:00-10:15	Lumping and identifiability		chair: Leon Aarons
09:00-09:35	Aris Dokoumetzidis	Tutorial: Lumping of compartments
09:35-09:55	Jin Jin	Model-Based Meta-Analysis for the Efficacy and Safety of Paclitaxel in Cancer Patients
09:55-10:15	Yasunori Aoki	A practical algorithm for practical parameter identifiability analysis
10:15-10:25	Preview of PAGE 2013
10:25-10:55	Coffee break
10:55-12:15	Variability models and optimal design		chair: Marylore Chenel
10:55-11:15	Anne-Gaelle Dosne	A strategy for residual error modeling incorporating both scedasticity of variance and distribution shape
11:15-11:35	Ron Keizer	Extended NPDE diagnostics for the between-subject variability and residual error model
11:35-11:55	Camille Vong	Handling Below Limit of Quantification Data in Optimal Trial Design
11:55-12:15	France Mentré	Survey on the current use of optimal design approaches and the developments needed in adaptive optimal design for model based analysis performed amongst DDMoRe’s EFPIA members
12:15-12:25	Closing remarks
12:25-12:40	Audience input for the PAGE 2013 program