PopED
Joakim Nyberg, Stefanie Henning, Mats O. Karlsson and Andrew C. Hooker
Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden
PopED is a Optimal Experimental Design tool for Non-Linear Mixed Effect Models [1]. Key features of PopED include the ability to optimize over multiple possible models as well as to assume distributions about model parameter values (ED-optimal design). PopED allows the user to optimize over any design variable (sample times, dose, number of individuals, start and stop time of experiments, infusion lengths and start times, etc...) greatly enhancing the information content of experiments. PopED 2 is written in Matlab and, for Windows users, a Graphical User Interface (GUI) is available. The PopED GUI is a Windows based program written in the language C# .NET 2.0 that wraps around the script version of PopED (written in Matlab) which performs the calculations needed to get an optimal design. The purpose of the GUI is to have an easy way to build up an experiment and to optimize the design variables in that experiment. The PopED GUI provides model templates and examples that will help the user to set up their own experiments and also provides tools for interpretation of the outcome of the optimal design and ways to validate models and simulate models prior to the optimal design. All these tools are also accessible via the script version of PopED. PopED is freely available at poped.sf.net.
[1]. Foracchia, M., et al., POPED, a software for optimal experiment design in population kinetics. Comput Methods Programs Biomed, 2004. 74(1): p. 29-46.
