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Lewis Sheiner


2017
Budapest, Hungary



2016
Lisboa, Portugal

2015
Hersonissos, Crete, Greece

2014
Alicante, Spain

2013
Glasgow, Scotland

2012
Venice, Italy

2011
Athens, Greece

2010
Berlin, Germany

2009
St. Petersburg, Russia

2008
Marseille, France

2007
KÝbenhavn, Denmark

2006
Brugge/Bruges, Belgium

2005
Pamplona, Spain

2004
Uppsala, Sweden
   Program
   Organisers
   Abstracts
   Participants

2003
Verona, Italy

2002
Paris, France

2001
Basel, Switzerland

2000
Salamanca, Spain

1999
Saintes, France

1998
Wuppertal, Germany

1997
Glasgow, Scotland

1996
Sandwich, UK

1995
Frankfurt, Germany

1994
Greenford, UK

1993
Paris, France

1992
Basel, Switzerland

Printable version
Thursday June 17
08:00-08:45 Registration and coffee
08:45-09:00 Welcome and Introduction
   
  Oral session I   chair: Janet Wade
09:00-09:30 Niclas Jonsson Graphical display of population data PDF of presentation
09:30-10:00 Al Maloney

Using SAS for non-linear mixed modelling – An overview PDF of presentation

10:00-11:00 Coffee break, Poster and Software session I
  Posters in Group I are accompanied by their presenter (see below)
  Oral session II   chair: Mats Karlsson
11:00-11:20 Annabelle Lemenuel-Diot Mixture Modelling for the Detection of Subpopulations in a Pharmacokinetic/Pharmacodynamic analysis PDF of presentation
11:20-11:40 Filip De Ridder Modelling and simulation of the incidence of adverse events in clinical trials PDF of presentation
11:40-12:00 Celine Dartois What is the Value of Uncertainty Parameter Estimates provided by Different Population PK Methods? PDF of presentation
12:00-12:30 Nick Holford Commemoration of Lewis Sheiner PDF of presentation
12:30-14:00 Lunch
  Oral session III Methodology session I chair: Niclas Jonsson
14:00-14:20 Christoffer Wenzel Tornøe Stochastic differential equations in NONMEM zipped PDF of presentation (save and open)
14:20-14:40 Niels Rode Kristensen Using Stochastic Differential Equations for PK/PD Model Development PDF of presentation
14:40-15:00 Stephen Duffull A real time optimal design for model discrimination and parameter estimation for itraconazole population PK PDF of presentation
15:00-16:00 Tea, Posters and Software
  Oral session IV Methodology session II chair: France Mentré
16:00-16:20 In-Sun Knutsson Bayesian analysis of a patient dataset using prior information from normal volunteers and from another patient group PDF of presentation
16:20-16:40 Adeline Samson Stochastic Approximation EM algorithm in nonlinear mixed effects models: an evaluation by simulation PDF of presentation
16:40-17:00 Robert Leary Accurate Maximum Likelihood Estimation for Parametric Population Analysis PDF of presentation
       
17:00-17:30 Planning of future PAGE meetings, preview PAGE 2005
 
19:00-24:00 Social Evening  
   
 
Friday June 18
  Oral session V   chair: Mick Looby
09:00-09:30 Thierry Lave PK extrapolation from animal to man: the good, the bad and the ugly. An overview of the performance of different methods applied across the project portfolio at Roche
09:30-09:50 Ronald Gieschke Incorporating uncertainty and variability into PBPK based predictions of human PK PDF of presentation
09:50-10:10 Hui Kimko NONMEM Implementation of Cell Lifespan Models for Hematological Drug Effects PDF of presentation
10:10-11:10 Coffee, Poster and Software session II
  Posters in Group II are accompanied by their presenter (see below)
  Tutorial on adaptive designs   chair: Steve Duffull
11:10-11:50 Andy Grieve Adaptive Designs : Bayesian & Non-Bayesian Approaches PDF of presentation
  Oral session VI Adaptive designs chair: Steve Duffull
11:50-12:10 Mike Smith An adaptive design for dose-response using the Normal Dynamic Linear Model PDF of presentation
12:10-12:30 James Wright Adaptive dose-finding in two-dimensions: A phase 1 oncology example PDF of presentation
12:30-14:00 Lunch  
Oral session VII Paediatrics chair: Oscar della Pasqua
14:00-14:20 Iñaki Trocóniz Pharmacokinetic/Pharmacodynamic Modelling of the Analgesic Effects of Tramadol in the Paediatric Population PDF of presentation
14:20-14:40 Bruce Charles Population Modelling of the Absolute Bioavailability and Pharmacokinetics of Phenobarbitone in Infants with Seizures PDF of presentation
14:40-15:00 Jeff Barrett The Value of Priors and Prior Uncertainty in Clinical Trial Simulation: Case Study with Actinomycin-D in Children with Cancer PDF of presentation
15:00-16:00 Tea, Posters and Software
  Oral session VIII   chair: Oscar della Pasqua
16:00-16:20 Chantaratsamon Dansirikul Bayesian Population Pharmacokinetic Analysis of Sirolimus
16:20-16:40 Radojka Savic Evaluation of a transit compartment model versus a lag time model for describing drug absorption delay PDF of presentation
16:40-17:00 Nick Holford Disease Progression in Parkinson's Disease - Evidence for Protective Effects of Drug Treatment PDF of presentation
17:00-17:05 Concluding remarks

Software abstracts

Marc Lavielle SAEM in MATLAB: an alternative to linearization

Posters Thursday (group I)

1. Anthe Zandvliet Population pharmacokinetics of caffeine and its metabolites theobromine, paraxanthine and theophylline after inhalation in combination with diacetylmorphine poster as zipped pdf
5. Sophie Gisbert Different approaches to the development of a WBPBPK model with a series of barbiturates using population modelling
7. Kayode Ogungbenro The Design of Population Pharmacokinetic Studies: Sample Size Determination
9. Thorsten Lehr Clock time as a control variable for gall bladder emptying in an enterohepatic circulation model poster as pdf
11. Elaine Blair Pharmacokinetic-Pharmacodynamic Modelling of Raltitrexed in Patients with Advanced Solid Tumours
13. Holger Kraiczi Effect of Uncertainty About Population Parameters on Pharmacodynamics-Based Prediction of Clinical Trial Power - A Method for Sensitivity Analysis poster as pdf
15. Bart Ploeger The reversal of rocuronium-induced neuromuscular block by the cyclodextrin ORG25969: model development and validation poster as pdf
17. Teun Post A Mechanistic Disease Progression Model for Type 2 Diabetes Mellitus and Pioglitazone Treatment Effects poster as pdf
19. Mike Smith A Bayesian design and analysis for dose-response using informative prior information poster as pdf
21. Elspeth Lamont Population Pharmacokinetics of Teicoplanin in Outpatient Home Parenteral Antibiotic Therapy (OHPAT) poster as pdf
23. Matthew Zierhut Development and Evaluation of a Population PK/PD Model for Fc-OPG in Healthy Postmenopausal Women poster as zipped pdf
25. Aris Dokoumetzidis Propagation of population pharmacokinetic information using a Bayesian approach poster as pdf
27. Marc Pfister Characterization of Cortisol Circadian Rhythm and Lack of Cortisol Suppression by a New Corticosteroid, Ciclesonide poster as pdf
29. Vladimir Piotrovsky Population pharmacokinetic analysis of concentration data after implantation of sirolimus-eluting Bx Velocity stent in patients poster as pdf
31. Karl-Heinz Liesenfeld Population pharmacokinetics of a new anticoagulant drug in clinical development poster as pdf
33. Jean-Eric Charoin Population Pharmacokinetic Analysis of Trastuzumab (Herceptin) following Long-Term Administration Using Different Regimens poster as pdf
35. Jeff Barrett Esmolol Population Pharmacokinetics in Critically-ill, Pediatric Patients poster as pdf
37. Jakob Ribbing Learning about Covariate Relations in the Patient Population Based on Data from Multiple Studies – Consequences of Different Approaches poster as pdf
39. Lena Friberg Simultaneous fit of competing models as a model discrimination tool in Bayesian analysis poster as pdf
41. Hugo Maas Comparison of sumatriptan and naratriptan using a markov model approach poster as pdf
43. Francesco Fiorentini An example of application of the population approach to toxicological studies poster as ppt
45. Annick Rousseau Modeling the complex pharmacokinetic profiles of cyclosporin and of mycophenolate observed in the early post-transplantation period poster as pdf
47. An Vermeulen Modeling the occurrence of orthostasis using a longitudinal logistic regression model
49. Brian Mc Hugh Population PK and PK/PD Analyses of an Enzyme Inhibitor in Healthy Volunteers poster as pdf
51. Lia Liefaard Application of Population Pharmacokinetic Analysis for Quantification of in vivo Binding Properties in the Rat Brain by Positron Emission Tomography poster as pdf
53. Willi Weber Comparing efficacy of 10mg vs 20mg ARAVA in treatment of rheumatoid arthritis: A Population PK / PD Analysis poster as pdf
55. Rune Overgaard Non-Linear Mixed Effects Models with Stochastic Differential Equations - Implementation of an Estimation Algorithm poster as pdf
57. John Lukas The cytochrome P450 3AP1 variant genotype shows correlation with the true clearance in a renal transplant population poster as pdf

Posters Friday (group II)

2. Daniel Jonker Development and validation of a mechanism-based PK/PD model for the in vitro-in vivo prediction of QT prolongation by dofetilide poster as pdf
4. Monica Simeoni Population modeling of tumor growth inhibition in vivo: application to anticancer drug development poster as pdf
6. Xuejun Chen Population Pharmacodynamic Analysis of QTc Prolongation vs. Plasma Concentration
8. Michael Dodds A Population PK Model for Recombinant Factor XIII in Healthy Volunteers
10. Florence Hourcade-Potelleret Population PK Analysis in Sparse Data and Flexible Sampling Time Conditions poster as pdf
12. Emmanuelle Comets Cerebral uptake of mefloquine enantiomers with and without theP-gp inhibitor elacridar (GF1210918) in mice poster as pdf
14. Kristin Cecilie Carlsson Can clinically useful population PK models for carbamazepine in pediatric epilepsy patients be developed based on routine therapeutic drug monitoring (TDM) data? poster as pdf
16. Sandra Visser Modeling of drug- and system-related changes in body temperature: application to drug-induced hypothermia, long-lasting tolerance development and diurnal variation in body temperature poster as pdf
18. Bernard Vrijens Identifying and minimizing major sources of variability in population pharmacokinetic studies poster as pdf
20. Lutz Harnisch A Population PK/PD Model for Cortisol Suppression
22. Karl Brendel Comparison of several prediction errors on concentrations for model evaluation poster as ppt
24. Michael Dodds Robust Population Pharmacokinetic Experiment Design
26. Klaas Zuideveld Quantification of 5-HT7 receptor efficacy distribution throughout the canine stomach using the operational model of agonism.
28. Nils Ove Hoem A non-parametric (NPAG) population PK model of orally and intravenously administered linezolid.
30. Andrew Hooker Evaluating the predictive power of the Fisher information matrix in population optimal experimental design poster as pdf
32. Sylvie Retout Comparison between the Fedorov-Wynn algorithm and the Simplex algorithm for population designs optimisation using a model of the HIV viral load decrease
34. Marta Valle Population pharmacokinetic/pharmacodynamic modeling of the possible tolerance development after a single oral dose of different BZD-GABAa agonists.
36. Maria Kjellsson Fitting Proportional Odds model to Ordered Categorical Data using the NLMIXED Procedure poster as pdf
38. Onintza Sayar Beristain Comparison of different models to describe simultaneously the kinetics of parent drug and metabolites after oral administration poster as zipped pdf
40. Niels Rode Kristensen A Deconvolution Method for Linear and Nonlinear Systems based on Stochastic Differential Equations poster as pdf
42. Dymphy Huntjens Population semi-parametric modelling of the pharmacokinetics of rofecoxib in rats poster as pdf
44. Italo Poggesi Population modeling of tumor growth in untreated xenografted mice poster as pdf
46. Maria Garrido Modelling of the effect of Topotecan on B cell subsets in tumor bearing rats poster as zipped pdf
48. Lars Lindbom PsN Toolkit, a collection of computer intensive methods for population PK/PD
50. Justin Wilkins A population pharmacokinetic-enzyme model for rifampicin autoinduction and bimodal absorption in pulmonary tuberculosis patients poster as pdf
52. Carl Kirkpatrick Population pharmacokinetic analysis of high-dose oral busulphan for bone marrow transplant in adults and children poster as pdf
54. Hanna Silber A disease model for the regulation of the glucose-insulin system poster as pdf
56. Claire Ambery Population Pharmacokinetics and Response of ICL670 a Novel Oral Iron Chelator in Beta-Thalassaemia Patients poster as pdf