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Lewis Sheiner

Budapest, Hungary

Lisboa, Portugal

Hersonissos, Crete, Greece

Alicante, Spain

Glasgow, Scotland

Venice, Italy

Athens, Greece

Berlin, Germany

St. Petersburg, Russia

Marseille, France

KÝbenhavn, Denmark

Brugge/Bruges, Belgium

Pamplona, Spain

Uppsala, Sweden

Verona, Italy

Paris, France

Basel, Switzerland

Salamanca, Spain

Saintes, France

Wuppertal, Germany

Glasgow, Scotland

Sandwich, UK

Frankfurt, Germany

Greenford, UK

Paris, France

Basel, Switzerland

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Tuesday 7 June


14:00-18:00 Registration at the Conference Venue
19:30-21:00 Welcome reception


Wednesday 8 June


08:00-08:45 Registration
08:45-09:00 Welcome and Introduction
09:00-10:20 Immune response to drug treatment and immunotherapy

Chair: Oscar Della Pasqua, Dinesh De Alwis

09:00-09:40 Nigel Klein A biological perspective on immune response to drug treatment (intended and unintended effects)
09:40-10:00 Hans Peter Grimm Intricate PK and PD for the novel immunocytokine CEA-IL2v and their pre-clinical to clinical translation
10:00-10:20 Kirill Peskov Investigation of anti-CTLA-4 immuno-oncology therapy through a quantitative systems pharmacology model
10:20-11:40 Coffee break, Poster and Software session I
  Posters in Group I (with poster numbers starting with I-) are accompanied by their presenter
11:40-12:20 Systems pharmacology

Chair: Charlotte Kloft

11:40-12:00 Kapil Gadkar A Six-Stage Workflow for Robust Application of Systems Pharmacology
12:00-12:20 Rob van Wijk The zebrafish as model for translational systems pharmacology: expanding the allometric scale in vertebrates with five orders of magnitude
12:20-13:50 Lunch
13:50-15:05 Growth (I)

Chair: Leon Aarons, Shasha Jumbe

13:50-14:05 Shasha Jumbe Introduction to the Gates' Healthy Birth, Growth & Development knowledge integration project
14:05-14:45 Louise Ryan Trajectory modelling based on early childhood longitudinal growth data
14:45-15:05 Niclas Jonsson Determinants for physical growth patterns in low- and middle-income countries
15:05-15:10 Announcement of WCoP 2016

Nick Holford

15:10-16:40 Tea break, Poster and Software session II
  Posters in Group II (with poster numbers starting with II-) are accompanied by their presenter
16:40-17:20 Growth (II)

Chair: Leon Aarons, Shasha Jumbe

16:40-17:00 Mélanie Wilbaux Characterizing and Forecasting Individual Weight Changes in Term Neonates
17:00-17:20 Nick Holford Growth and decline of body size and composition – Prediction of the transition from pre-diabetes to Type 2 diabetes in humans
17:40-18:20 Other applications

Chair: Leon Aarons, Shasha Jumbe

17:40-18:00 Thi Huyen Tram Nguyen The paradox of highly effective sofosbuvir combo therapy despite slow viral decline
18:00-18:20 Rik Schoemaker Extrapolation of a Brivaracetam Exposure-Response Model from Adults to Children
18:30-18:50 Special surprise...


Thursday 9 June


08:45-10:05 Lewis Sheiner Student Session

Chair: Marylore Chenel, Aris Dokoumetzidis, Leonid Gibiansky

08:45-09:10 Elin Svensson Bedaquiline's exposure-response relationship revealed through modeling of mycobacterial load
09:10-09:35 Solène Desmée Joint modelling for nonlinear longitudinal PSA kinetics and survival data in metastatic prostate cancer patients
09:35-10:00 Stein Schalkwijk A physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women
10.00-10.05 Presentation of Lewis Sheiner student session awards
10:05-11:30 Coffee break, Poster and Software session III
  Posters in Group III (with poster numbers starting with III-) are accompanied by their presenter
11:30-12:30 Oncology

Chair: Ana Ruiz

11:30-11:50 Matts Kågedal Time-to-Event Modeling of Peripheral Neuropathy – Platform Mega-Analysis of Eight vc-MMAE Antibody-Drug Conjugates (ADCs)
11:50-12:10 Lucy Hutchinson Mathematical modelling of transient tumour growth dynamics following anti-angiogenic therapy
12:10-12:30 Maria Luisa Sardu Modelling of classified individual tumor lesions in metastatic colorectal cancer (mCRC) patients using delay differential equations
12:30-13:50 Lunch
13:50-14:35 Tutorial: Estimation methods

Chair: France Mentré

13:50-14:35 Robert Bauer An overview of Estimation-Maximization Algorithms Used in Population Analysis Methods
14:35-14:40 Announcement of ACoP7

Brian Corrigan

14:40-16:00 Tea break, Poster and Software session IV
  Posters in Group IV (with poster numbers starting with IV-) are accompanied by their presenter
16:00-17:20 Stuart Beal Methodology Session

Chair: Paolo Magni

16:00-16:20 Yevgen Ryeznik Adaptive dose finding for time-to-event outcomes with adaptive choice of patient number based on response rate
16:20-16:40 Sebastian Wicha A general pharmacodynamic interaction model based on the Bliss Independence criterion
16:40-17:00 Martin Fink Improving priors for human mAb linear PK parameters by using half-lives from pre-clinical studies
17:00-17:20 David McDougall The Impact of Model Selection for Personalised Dosing
20:00-01:00 Social event: Buses depart from the Conference Venue at 19:30


Friday 10 June


09:00-10:00 Model-based approaches to aid in choice of dose and study design

Chair: Justin Wilkins

09:00-09:20 Lutz Harnisch Modelling and simulation of neurological endpoints (modified Rankin Scale [mRS] and National Institute of Health Stroke Scale [NIHSS]) to aid clinical trial design in intracerebral hemorrhage (ICH)
09:20-09:40 Oliver Sander Model-based development of the secukinumab dosing regimen for the treatment of moderate-to-severe chronic plaque psoriasis
09:40-10:00 Rasmus Vestergaard Juul Repeated time to event modelling of opioid consumption in postoperative pain
10:00-10:20 Thu Thuy Nguyen Limited sampling strategy for a population pharmacokinetic modelling of cocktail of phenotyping drugs
10.20-10.30 Preview of PAGE 2017
10:30-11:00 Coffee break and Software session
11:00-12:00 Central Nervous System Diseases

Chair: Nick Holford

11:00-11:20 Sylvie Retout How disease modeling and model-based meta-analyses contributed to understanding the path forward after dose discontinuation of a Phase III study in Alzheimer's disease
11:20-11:40 Marc Vandemeulebroecke A longitudinal Item Response Theory model to characterize cognition over time in elderly subjects
11:40-12:00 Simon Buatois Utilizing the items from the MDS-UPDRS score to increase drug effect detection power in de novo idiopathic Parkinson's disease
12.00-12.10 Closing remarks
12:10-12:30 Audience input for potential PAGE2017 topics