Welcome to the Population Approach Group in Europe

Tuesday

18:30-21:30	Registration at the Conference Venue


18:30-21:30	Opening Ceremony, Welcome Reception


Wednesday

8:00-8:45	Registration at the Conference


8:45-9:00	Welcome and Introduction		Oscar Della Pasqua and Thomas Dorlo

9:00-10:00	New Modeling Approaches		Marylore Chenel & Rob ter Heine

9:00-9:20	Nikolaos Alimpertis	The estimates for the absorption rate constant in pharmacokinetics and pharmacometrics are wrong: A new era based on the finite absorption time concept rises

9:20-9:40	Robin Chaux	Meta-analysis of parameter estimates of non-linear mixed effect models using Approximate Bayesian Computation: application to population pharmacokinetics

9:40-10:00	Mohamed Gewily	A Semi Parametric Method for the Estimation of End of Treatment Effect

10:00-11:30	Coffee Break, Software, and Poster Session I


11:30-12:30	Pediatric Extrapolation		Kristin Karlsson, Nick Holford, & Rocio Lledo

11:30-11:50	Kristin Karlsson	Paediatric Extrapolation - Opportunities and Challenges

11:50-12:10	Italo Poggesi	Extrapolating treatment to children less than 6 years old: the successful story of velmanase alfa in alpha-mannosidosis

12:10-12:30	Bart van Lieshout	Population pharmacokinetic analysis of guanabenz in children with Vanishing White Matter: Evaluating scaling adult drug safety and pharmacokinetics data

12:30-14:00	Lunch


14:00-14:50	A tutorial on machine learning & pharmacometrics		Gilbert Koch & Martin Bergstrand

14:00-14:50	Nadia Terranova and Uri Nahum	Artificial Intelligence and Machine Learning for Next-Generation Model-Informed Precision Medicine: A Tutorial on Practical Applications and Pitfalls

14:50-15:30	Machine Learning in Pharmacometrics		Gilbert Koch & Martin Bergstrand

14:50-15:10	Antari Khot	Do tree-based machine learning methods outperform Cox regression for progression-free survival prediction in mobocertinib treated lung cancer patients?

15:10-15:30	Ana Victoria Ponce Bobadilla	Benefits of integrating machine learning with clinical pharmacology principles for predictive pharmacokinetic modeling

15:30-15:35	RedIF Announcement		Darlene Santiago

15:35-17:00	Coffee Break, Software, and Poster Session II


17:05-17:45	Neurodegenerative diseases		Monica Simeoni

17:05-17:25	Alzahra Hamdan	Item Response Theory Analysis of the Scale for the Assessment and Rating of Ataxia in Autosomal Recessive Cerebellar Ataxias

17:25-17:45	Alessio Paris	An age-dependent QSP model of Nf trafficking to optimize treatment in neurodegenerative diseases

Thursday

8:30-10:10	Lewis Sheiner Student Session		Paolo Denti, Maria Kjellsson, and Stefanie Hennig

8:30-8:55	Conor O'Hanlon	A framework for drug pharmacokinetics during cardiopulmonary bypass

8:55-9:20	Alexander Janssen	A generative and causal pharmacokinetic model for haemophilia A: towards an unified model for all factor VIII concentrates.

9:20-9:45	Alessandro De Carlo	Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat

9:45-10:10	Alexandra Lavalley-Morelle	Joint modeling of biomarkers dynamics and survival with competing risks to predict the prognostic of patients hospitalized with severe infectious diseases

10:10-10:15	Presentation Lewis Sheiner Student Session Awards


10:15-11:45	Coffee Break, Software, and Poster Session III


11:45-12:25	Modelling Antibody Responses		Thomas Dorlo

11:45-12:05	I�aki F. Troc�niz	Modeling the dynamics of anti-drug antibodies in cancer patients treated with oncolytic virus in monotherapy or in combination with immune check- point inhibitors

12:05-12:25	Quentin Clairon	Modeling the kinetics of the neutralizing antibody response against SARS-CoV-2 variants after several administrations of Bnt162b2 vaccine

12:25-13:55	Lunch


13:55-14:40	Keynote Lecture		Dinesh de Alwis & Lena Friberg

13:55-14:40	Alexandra Snyder	Current and future applications of circulating tumor DNA (ctDNA) to oncology drug development

14:40-15:20	Tumor Growth Dynamics		Dinesh de Alwis & Lena Friberg

14:40-15:00	Yomna Nassar	A joint tumour dynamics and C-reactive protein turnover model to identify early longitudinal prognostic predictors of overall survival in advanced non-small cell lung cancer patients

15:00-15:20	Anna Kondic	The combined use of propensity score matching and a joint tumor growth dynamics (TGD) - Overall Survival (OS) model to benchmark the efficacy of new treatments for advanced renal cell carcinoma (RCC)

15:20-15:25	ACoP Announcement		Wei Gao

15:25-16:55	Coffee Break, Software, and Poster Session IV


16:55-17:55	Stuart Beal Methodology Session		Ana Ruiz

16:55-17:15	Freya Bachmann	Computing Optimal Drug Dosing with Constraints on Model States in NONMEM

17:15-17:35	Dominic Br�m	Neural ODE structures based on pharmacokinetic principles

17:35-17:55	Zhonghui Huang	Development and exploration of exhaustive, stepwise, and heuristic algorithms for automated population pharmacokinetic modelling

20:30-2:00	Social Event


Friday

9:15-10:15	QSP & PBPK Disease Models		Oscar Della Pasqua

9:15-9:35	Joey Leung	Virtual population analysis of a Quantitative Systems Pharmacology (QSP) model of atopic dermatitis (AtD) to evaluate AtD treatments

9:35-9:55	Natalia Riva	Expanding a quantitative systems pharmacology (QSP) modeling framework for acute Hepatitis B to characterize chronic infection

9:55-10:15	Robin Michelet	Development and Application of a Minimal Physiology-based Pharmacokinetics Modelling Framework to Predict Tumor Penetration and Receptor Occupancy.

10:15-10:20	Preview of PAGE 2024


10:20-10:55	Coffee Break


10:55-11:55	Model Diagnostics		Siv J�nsson

10:55-11:15	Martin Bergstrand	Application relevant shrinkage metrics

11:15-11:35	Sarah Baklouti	Multivariate Exact Discrepancy : a new tool for PK/PD model evaluation

11:35-11:55	Stefanie Hennig	Considerations when deriving time-averaged exposure for censored subjects for logistic regression exposure-response analyses

11:55-12:05	Closing remarks


12:05-12:20	Audience Input for potential PAGE 2024 topics