Welcome to the Population Approach Group in Europe

Tuesday

09:30-17:30	Registration at the conference venue


19:30-21:30	Welcome reception with drinks and light snacks (no dinner)


Wednesday

08:00-08:45	Registration at the conference venue


08:45-09:00	Welcome and introduction		Oscar della Pasqua & Thomas Dorlo

09:00-09:45	Keynote lecture		Rocio Lledo-Garcia & Zinnia Parra Guillen

09:00-09:45	Iain Gardner	Pre-clinical and clinical applications of PBPK models for monoclonal antibodies and other large molecule modalities.

09:45-11:15	Coffee break, Poster and Software Session I


11:15-12:15	Immunogenicity		Rocio Lledo-Garcia & Zinnia Parra Guillen

11:15-11:35	Hans Peter Grimm	Learn-and-Confirm in Quantitative Systems Pharmacology: Evaluation of an Immunogenicity Platform

11:55-12:15	Rory Leisegang	Immunogenicity dynamics and covariate effects after satralizumab administration predicted with a Hidden Markov Model

11:35-11:55	Alix D�maris	Towards understanding anti-infliximab antibody development to predict Crohn�s disease patients' underlying immunogenicity status

12:15-13:45	Lunch


13:45-14:25	Automatic Model Development		Gilbert Koch

13:45-14:05	Xiaomei Chen	Development of a tool for fully automatic model development (AMD)

14:05-14:25	Marc Lavielle	SAMBA: a new algorithm for automatic construction of nonlinear mixed-effects models.

14:25-15:05	Model-Informed Precision Dosing		Stefanie Hennig & Ana Ruiz

14:25-14:45	Ron Keizer	Composite Importance Sampling (CIS) for continuous learning in precision dosing

14:45-15:05	Benjamin Ribba	Population model-enhanced reinforcement learning to enable precision dosing: case study with dosing of propofol for sedation

15:05-15:10	Special Announcement


15:10-16:40	Coffee break, Poster and Software Session II


16:40-17:20	Modelling Other Pharmacological Aspects		Siv J�nsson & Monica Simeoni

16:40-17:00	Orwa Albitar	Pharmacometric Modeling of Drug Adverse Effects: An Application of Mixture Models in Schizophrenia Spectrum Disorder Patients Treated with Clozapine

17:00-17:20	Jurgen Langenhorst	An item response theory model with bounded integer subcomponents to describe the Mayo Clinic subscores in patients with ulcerative colitis

Thursday

08:30-09:50	Lewis Sheiner Student Session		Al Maloney, Nadia Terranova & Justin Wilkins

08:30-08:55	Kamunkhwala Gausi	A semi-mechanistic model of the population pharmacokinetics and bactericidal activity of high-dose isoniazid against multi-drug-resistant tuberculosis

08:55-09:20	Yu Fu	A translational cardiovascular systems model to quantify drug effects on contractility and other hemodynamic variables

09:20-09:45	Soumya Perinparajah	Mathematically Modelling CD19+ B Cell Reconstitution After Insult to the Immune System: Paediatric Allogeneic Haematopoietic Stem Cell Transplantation, Rituximab Therapy and Epstein-Barr Viral Reactivation

09:45-09:50	Presentation Lewis Sheiner Student Session Awards


09:50-11:20	Coffee break, Poster and Software session III


11:20-12:40	Infectious Diseases: SARS-CoV-2 & Tuberculosis		Thomas Dorlo & France Mentr�

11:20-11:40	Marie Alexandre	SARS-CoV-2 mechanistic correlates of protection in non-human primates: insight from modelling response to vaccines.

11:40-12:00	Alexandra Lavalley-Morelle	Longitudinal biomarkers predicting death of hospitalized patients for SARS-COV-2 infection: a joint analysis with competing risks

12:00-12:20	Jacqueline Ernest	Spatially and temporally resolved diffusion kinetics of bedaquiline and TBAJ-587 in hard-to-treat sites of TB disease

12:20-12:40	Federico Reali	PBPK/PD modeling and machine learning approaches to support the development of new drugs and regimens against tuberculosis.

12:40-12:45	ACoP Announcement		Anja Henningsson & Ana Ruiz

12:45-14:15	Lunch


14:15-15:00	Keynote Lecture		Oscar Della Pasqua

14:15-15:00	Filippo Castiglione	Modeling biology by agents

15:00-16:30	Coffee break, Poster, and Software Session IV


16:30-17:30	Stuart Beal Methodology Session		Emmanuelle Comets & Martin Bergstrand

16:30-16:50	Sarah Baklouti	A methodology to de-shrink Empirical Bayes Estimates

16:50-17:10	Thomas Bouillon	Dose selection by covariate assessment on the optimal dose for efficacy � application of machine learning in the context of PKPD

17:10-17:30	Laura Zwep	Copula modeling for realistic virtual patient covariate simulation

20:00-00:00	Social Event


Friday

09:15-10:35	Oncology		Dinesh de Alwis & Rene Bruno

09:15-09:35	Zinnia Parra-Guillen	A physiologically-based pharmacokinetic/pharmacodynamic framework to support clinical development of V937, a novel oncolytic virus

09:35-09:55	Marion Kerioui	Joint modelling of individual target lesions and survival to characterize the variability in the response to immunotherapy versus chemotherapy in advanced bladder cancer

09:55-10:15	Sebastien Benzekry	Supporting decision making and early prediction of survival for oncology drug development using a pharmacometrics-machine learning based model.

10:15-0:35	Sarah Lobet	Target-response relationship of bevacizumab may be more relevant than exposure-response - a target-mediated drug disposition (TMDD) model

10:35-10:40	Preview of PAGE 2023


10:40-11:15	Coffee break


11:15-11:55	Real-World Data in Oncology		Pascal Girard

11:15-11:35	Perrine Courlet	Modelling real-world tumor size dynamics based on electronic health records and image data in advanced melanoma patients receiving immunotherapy

11:35-11:55	Luca Marzano	Introducing a novel analytical framework for risk stratification of real-world data with survival and unsupervised machine learning. A small cell lung cancer SCLC study

11:55-12:05	Closing Remarks		Oscar Della Pasqua

12:05-12:20	Audience input for PAGE 2023 Scientific Programme		Chair: Thomas Dorlo