The Lewis Sheiner Student Session
In 2005, the PAGE organising committee inaugurated the annual Lewis Sheiner Student Session, both to honour the memory of Lewis Sheiner and to highlight his lifetime passion for student education. Students wishing to be considered for inclusion in this session should submit an extended abstract of their intended presentation for the PAGE meeting. A structured abstract is required (Objectives/ Methods/ Results/ Conclusion/ References) with number of characters (including spaces) not exceeding 7,000 but not less than 6,000 for the abstract itself (i.e. excluding Title/ Authors/ Affiliation and References). The submitted work must have been performed either as an MSc or PhD student, or with the goal that the submitted work will ultimately form part of a PhD thesis. Both 'regular' academic students and candidates with industry affiliations preparing a PhD thesis are invited.
Each year a rotating committee of three members, representative of the PAGE community, will judge who should receive the honour of presenting in the Lewis Sheiner Student Session. The committee consists of one volunteering member of the PAGE Scientific Organizing Committee (SOC), or Advisors, and the other 2 members are nominated by the SOC/Advisors and are regular PAGE participants who have made substantial contributions to PAGE in the past. Diversity and inclusiveness in representation are prioritized by the SOC/Advisors when constituting the review committee annually.
If elected, the candidate will automatically receive a PAGE-sponsored 300 € award (on top of potential other grants). A permanent list of students, with links to their presentation, will be maintained below.
Lewis Sheiner Student Session abstracts are always reviewed by removing authors, affiliations, and acknowledgements, to blind the reviewers to the origin of the abstract. If a reviewer detects one of the abstract as originating from their group, their vote for that abstract is abstained and replaced by the average of the other two votes.
2024
The committee for 2024 consisted of Siv Jönsson, Jérémie Guedj, and Coen van Hasselt, and elected the following students (with links to their presentations):
- Wendy Chu: Optimizing dosing strategies for post-kala-azar dermal leishmaniasis: a geographical comparison of systemic and skin pharmacokinetics and pharmacodynamics of antileishmanial drugs
- Selma El Messaoudi: Mechanistic modeling of the long-term dynamics of viral markers to predict the outcome of combination therapy in chronic HBV and HDV infections
- Julie Dudasova: Logistic regression-based approach to assess heterogeneity in vaccine efficacy using immunogenicity measurements in phase 3 clinical trials
2023
The committee for 2023 consisted Paolo Denti, Maria Kjellsson, and Stefanie Hennig, and elected the following students (with links to their presentations):
- Conor O'Hanlon: A framework for drug pharmacokinetics during cardiopulmonary bypass
- Alexander Janssen: A generative and causal pharmacokinetic model for haemophilia A: towards an unified model for all factor VIII concentrates.
- Alessandro De Carlo: Integrating Reinforcement Learning and PK-PD modelling to enable precision dosing: a multi-objective optimization for the treatment of Polycithemia Vera patients with Givinostat
- Alexandra Lavalley-Morelle: Joint modeling of biomarkers dynamics and survival with competing risks to predict the prognostic of patients hospitalized with severe infectious diseases
2022
The committee for 2022 consisted of Al Maloney, Nadia Terranova and Justin Wilkins, and elected the following students (with links to their presentations):
- Kamunkhwala Gausi: A semi-mechanistic model of the population pharmacokinetics and bactericidal activity of high-dose isoniazid against multi-drug-resistant tuberculosis
- Yu Fu: A translational cardiovascular systems model to quantify drug effects on contractility and other hemodynamic variables
- Soumya Perinparajah: Mathematically Modelling CD19+ B Cell Reconstitution After Insult to the Immune System: Paediatric Allogeneic Haematopoietic Stem Cell Transplantation, Rituximab Therapy and Epstein-Barr Viral Reactivation
2021
The committee for 2021 consisted of Juan José Perez-Ruixo, Kayode Ogungbenro and Stacey Tannenbaum, and elected the following students (with links to their presentations):
- Linda Aulin: Model-based design of innovative treatment strategies to suppress antimicrobial resistance using collateral sensitivity
- Marion Kerioui: Bayesian modelling of individual lesions dynamics and survival to characterize response to immunotherapy cancer treatments
- Anna McLaughlin: Population quantitative systems pharmacology model of distinct CAR-T cell phenotypes and CD19-specific metabolic tumour volume reveals sources of high pharmacokinetic variability and overall survival
2020
The committee for 2020 consisted of Rocio Lledo-Garcia, Monica Simeoni, and Sandra Visser, and elected the following students (with links to their presentations):
- Rob van Wijk: Translational quantitative systems pharmacology; crossing borders between experimental and computational drug development using zebrafish as model organism
- Eleni Karatza: Machine-Learning for cancer treatment: Guided covariate selection for TTE models developed from real world data with a small number of patients
- Vincent Chang: In silico assessment of adaptive trial design for TB regimen development
2019
The committee for 2019 consisted of Emilie Hénin, Andrew Hooker, and Thomas Dorlo, and elected the following students (with links to their presentations):
- Moustafa Mahmoud Abdellatif Ibrahim: Competing risks analysis of the Finnish diabetes prevention study
- Sebastiaan Goulooze: Novel pharmacometric techniques to quantify and prevent iatrogenic withdrawal in children
- Elena Tosca: Dynamic Energy Budget (DEB) based models of tumor-in-host growth inhibition and cachexia onset
2018
The committee for 2018 consisted of Ana Ruiz, Alain Munafo, and Julie Bertrand, and elected the following students (with links to their presentations):
- Simon Buatois: A pharmacometric extension of MCP-MOD in dose finding studies
- Benjamin Guiastrennec: New dosing recommendations for anti-tuberculosis therapy in Indian children
- Jurgen Langenhorst: Cause-specific hazard models with markovian elements to quantify the fludarabine exposure-response relationship: from learning to confirming in allogeneic hematopoietic cell transplantation
- Gustaf Wellhagen: A bounded integer model for rating and composite scale data
2017
The committee for 2017 consisted of Kristin Karlsson, Julia Winkler, and Paolo Magni and elected the following students (with links to their presentations):
- Elisa Borella: Paediatric trial design optimization using prior knowledge in combination with modelling & simulations
- John Diep: Host-Pathogen interactions: A mechanism-based disease progression model to describe the pathogenesis of Acinetobacter baumannii pneumonia
- Morris Muliaditan: Model-based rationale for drug combinations in tuberculosis
2016
The committee for 2016 consisted of Marylore Chenel, Aris Dokoumetzidis and Leonid Gibiansky and elected the following students (with links to their presentations):
- Elin Svensson: Bedaquiline's exposure-response relationship revealed through modeling of mycobacterial load
- Solène Desmée: Joint modelling for nonlinear longitudinal PSA kinetics and survival data in metastatic prostate cancer patients
- Stein Schalkwijk: A physiologically-based population pharmacokinetic analysis to assess a lower efavirenz dose of 400 mg once daily in HIV-infected pregnant women
2015
The committee for 2015 consisted of Rada Savic, Steven Kern and Michael Looby and elected the following students (with links to their presentations):
- Huixin Yu: Development of a tumour growth inhibition model to elucidate the effect of ritonavir on intratumoural metabolism and anti-tumour effect of docetaxel in a mouse model for hereditary breast cancer
- Shan Pan: Automated proper lumping for simplification of systems models
- Adrien Tessier: Modelling pharmacogenetic data in population studies during drug development
2014
The committee for 2014 consisted of Emanuelle Comets, Panos Macheras and Joachim Grevel and elected the following students (with links to their presentations):
- Thi Huyen Tram Nguyen: Handling data below the quantification limit in viral kinetic modeling for model evaluation and prediction of treatment outcome
- Nikolaos Tsamandouras: Development of population based approaches to describe the complex pharmacokinetics of simvastatin in different individuals. Bridging the gap between population and physiologically based pharmacokinetic modelling
- Mélanie Wilbaux: A dynamic K-PD joint model for the kinetics of CTC (Circulating Tumor Cell) count and PSA concentration during treatment in metastatic castration-resistant prostate cancer
2013
The committee for 2013 consisted of Philippe Jacqmin, Leon Aarons and Lena Friberg and elected the following students (with links to their presentations):
- Abhishek Gulati: Simplification of a multi-scale systems coagulation model with an application to modelling PKPD data
- Nelleke Snelder: Mechanism-based PKPD modeling of cardiovascular effects in conscious rats - an application to fingolimod
- Nadia Terranova: Mathematical models of tumor growth inhibition in xenograft mice after administration of anticancer agents given in combination
2012
The committee for 2012 consisted of Dinesh Dealwis, Katya Gibiansky and Pascal Girard and elected the following students (with links to their presentations):
- Thomas Dorlo: Translational pharmacokinetic modelling and simulation for the assessment of duration of contraceptive cover after use of miltefosine for the treatment of visceral leishmaniasis
- Sebastian Ueckert: Application of Item Response Theory to ADAS-cog Scores Modelling in Alzheimer’s Disease
2011
The committee for 2011 consisted of Alison Thomson, An Vermeulen and Niclas Jonsson and elected the following students (with links to their presentations):
- Abhishek Gulati: Linking in silico and in vitro experiments to identify and evaluate a biomarker for enoxaparin activity
- Joshua Pink: Pharmacokinetic-pharmacodynamic-pharmacoeconomic analysis of rituximab for follicular lymphoma
- Elodie Plan: Modelling Techniques Handling Dynamic Pain Scores Characteristics
2010
The committee for 2010 consisted of Chantal Csajka, Ferdie Rombout and Willi Weber and elected the following students (with links to their presentations):
- Caroline Bazzoli: Design evaluation and optimisation in multi-response nonlinear mixed effect models with cost functions: application to the pharmacokinetics of zidovudine and its active metabolite
- Maud Delattre: Estimation of mixed hidden Markov models with SAEM. Application to daily seizures data
- Lay Ahyoung Lim: Dose-Response-Dropout Analysis for Somnolence in Pregabalin-treated Patients with Generalized Anxiety Disorder
2009
The committee for 2009 consisted of Charlotte Kloft, Iñaki Trocóniz and Oscar Della Pasqua and elected the following students (with links to their presentations):
- Julie Antic: Nonparametric Methods: When to use them? Which method to choose?
- Elena Soto: Prediction of haematological effects of a new combination of anticancer drugs, BI 2536 (a PLK1 inhibitor) and pemetrexed, using a semi-mechanistic population model for neutropenia
- Venkata Pavan Kumar Vajjah: Novel graphical diagnostics for assessing fit of logistic regression models
2008
The committee for 2008 consisted of Janet Wade, Sily Laporte and Stephen Duffull and elected the following students (with links to their presentations):
- Martin Bergstrand: Modeling of gastro-intestinal tablet transit and its’ effect on drug release and absorption for felodipine extended release tablet under fed or fasting conditions
- Jakob Ribbing: Modelling the Dynamics of Glucose, Insulin, Insulin Sensitivity and Beta-Cells in Subjects with Insulin Resistance and Patients with Type 2 Diabetes
- Thuy Vu: Time Course of Disease Status as a Predictor of Clinical Outcome in Parkinson’s Disease
2007
The committee for 2007 consisted of France Mentré, Nick Holford and René Bruno, and elected the following students (with links to their presentations):
- Karl Brendel: Normalized Prediction Distribution Error for the Evaluation of Nonlinear Mixed-Models
- Amy Cheung: Identifiability Analysis and Parameter List Reduction of a Nonlinear Cardiovascular PKPD Model
- Radojka Savic: Importance of Shrinkage in Empirical Bayes Estimates for Diagnostics and Estimation: Problems and Solutions
2006
The committee for 2006 consisted of Jean-Louis Steimer, Alison Thomson, Rik Schoemaker and Ted Grasela as special guest, and elected the following students (with links to their presentations):
- Emilie Hénin: A KPD Model for ordered categorical data: application to toxicity score in colorectal cancer patients treated with capecitabine
- Adeline Samson: The SAEM algorithm for non-linear mixed models with left-censored data and differential systems: application to the joint modeling of HIV viral load and CD4 dynamics under treatment
- Anthe Zandvliet: Semi-mechanistic PK/PD model of indisulam in combination with capecitabine: a time-dependent pharmacokinetic interaction contributes to excessive hematological toxicity
2005
The committee for 2005 consisted of Brigitte Tranchand, Jean-Louis Steimer and Willi Weber, and elected the following students (with links to their presentations):
- Xaviére Panhard: Non-linear mixed-effects models for tests of interaction or of lack of interaction in cross-over and parallel pharmacokinetic studies: application to the test of interaction between protease inhibitors and nucleoside analogs in HIV patients
- Maria Kjellsson: A Study Comparing the Performance of the Proportional Odds Model to that of the Differential Drug Effect Model for Cumulative Logits
- Petra Jauslin-Stetina: A Disease Model Describing the Regulation of the Glucose-Insulin System in Diabetic Patients after IVGTT and OGTT