Perl speaks NONMEM (PsN) and Xpose
Kajsa Harling, Andrew C. Hooker, Sebastian Ueckert, E. Niclas Jonsson, Mats O. Karlsson
Pharmacometrics group, Department of Pharmaceutical Biosciences, Uppsala University, Sweden
PsN is a toolbox for population PK/PD model building using NONMEM 6 and 7. It has a broad functionality ranging from results extraction from output files, data file sub setting and resampling, to advanced computer-intensive statistical methods and NONMEM job handling in large distributed computing systems. PsN includes stand-alone tools for the end-user as well as development libraries for method developers. New features include covariate model building functionality utilizing the cross-validation, linearization and lasso methods. The existing stepwise covariate model building tool has also undergone a major revision for increased flexibility and stability. In addition, handling of dropout censoring and missing observations in visual predictive checks and a new tool for Monte-Carlo mapped power have been implemented. <\P>
Xpose 4 is an open-source population PK/PD model building aid for NONMEM. Xpose attempts to facilitate the use of diagnostics in an efficient manner, providing a toolkit for dataset checkout, exploration and visualization, model diagnostics, candidate covariate identification and model comparison. <\P>
The cooperative functionality included in PsN and Xpose permits a synergistic use of both, allowing the end user to easily compute and display various predictive checks and other diagnostics. <\P>
Both Xpose and PsN are freely available at http://xpose.sourceforge.net and http://psn.sourceforge.net respectively.
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